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MolekylärbiologHeltidVanlig anställning

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Göteborgs universitet möter samhällets utmaningar med mångsidig kunskap. 58 000 studenter och 6800 medarbetare gör universitetet till en stor och inspirerande arbetsplats. Stark forskning och attraktiva utbildningar lockar forskare och studenter från hela världen. Med ny kunskap och nya perspektiv bidrar Göteborgs universitet till en bättre framtid. Institutionen för kliniska vetenskaper är en av sex institutioner vid Sahlgrenska akademin vid Göteborgs universitet. Vid institutionen bedrivs forskning och utbildning som sätter människans hälsa och livskvalitet i fokus. Vi representerar 16 olika ämnesområden (avdelningar) och är indelade i fyra sektioner. Genom ett berikande samarbete med sjukvården och Sahlgrenska Universitetssjukhuset har vi utvecklat samprojekt och mötesplatser som gynnar både vården och forskningen. Avdelningen för övre abdominalkirurgi bedriver forskning inom translationell och experimentell medicin med särskilt fokus på mekanismer bakom cancersjukdom och utveckling av relevanta modellsystem för att förstå sjukdomsprocesser på cellulär och molekylär nivå, med huvudfokus på pankreascancer. Verksamheten präglas av tvärvetenskapligt samarbete mellan klinisk och preklinisk forskning. Den aktuella forskningsgruppen inom pancreas cancer arbetar bland annat med humant deriverade cancer-celler för att modellera cancer sjukdom, inklusive cellelinjer men även patient-deriverade organoider från pancreas cancer och cancer neoplasier in vitro. Målsättningen är att utveckla och tillämpa avancerade cellmodeller för att studera sjukdomsmekanismer, med särskilt fokus på tumörmikromiljön och immunsystemet, samt skapa förutsättningar för framtida läkemedelstestning. Arbetsuppgifter Arbetsuppgifterna innefattar laborativt arbete inom ett forskningsprojekt med fokus på patient-deriverade organoider och cellsbaserad modellering av pankreascancer. Arbetsuppgifterna omfattar odling, hantering och experimentell bearbetning av humant deriverade celler från pankreastumörer, samt molekylärbiologiska och cellbiologiska metoder relevanta för projektets genomförande. Därutöver ingår dokumentation av experiment, kvalitetssäkring av laboratorieprocesser, sammanställning av resultat och praktisk medverkan i metodutveckling. Arbetet sker i nära samverkan med forskningsgruppen och förutsätter god förmåga att arbeta både självständigt och strukturerat i laborativ miljö. Kvalifikationer För anställningen krävs grundexamen inom molekylärbiologi, cellbiologi, biomedicin eller annat område som arbetsgivaren bedömer likvärdigt. Den sökande ska ha dokumenterad erfarenhet av laborativt arbete och god förmåga att uttrycka sig i tal och skrift på engelska. Det är meriterande med tidigare erfarenhet av arbete med cellmodeller, cellodlingar och cellmodeller inom pancreas neoplasier. Även bioinformatik och relevanta molekylärbiologiska metoder inom pankreascancer är meriterande. Erfarenhet av laborativ verksamhet inom Sahlgrenska Universitetssjukhusets miljö eller närliggande akademisk forskningsmiljö är också meriterande. Stor vikt kommer att läggas vid personlig lämplighet. Den sökande ska vara noggrann, ansvarstagande, ha god samarbetsförmåga och ett dokumenterat intresse för translationell laboratoriebaserad forskning. För mer information och för att söka anställningen, se annonsen i sin helhet på https://www.gu.se/om-universitetet/jobba-hos-oss/lediga-anstallningar. Universitetet arbetar aktivt för en arbetsmiljö med jämställda förhållanden och sätter värde på de kvalitéer mångfald tillför verksamheten. Universitetet tillämpar individuell lönesättning. Enligt Riksarkivets föreskrifter är universitetet skyldigt att förvara ansökningshandlingar i två år efter tillsättningsbeslutet. Om du som sökande till en anställning särskilt begär tillbaka dina handlingar återsänds de när de två åren har förflutit, i annat fall kommer de att gallras ut. Till bemannings- och rekryteringsföretag och till dig som är försäljare: Göteborgs universitet anlitar upphandlad annonsbyrå i samband med rekrytering av personal. Vi undanber oss vänligen men bestämt direktkontakt med bemannings- och rekryteringsföretag samt försäljare av jobbannonser.Öppen för alla Vi fokuserar på din kompetens, inte dina övriga förutsättningar. Vi är öppna för att anpassa rollen eller arbetsplatsen efter dina behov.

Arbetsplatsadress

Blå Stråket 15, vån 3 SU/Sahlgrenska, 40530 Göteborg

Sista ansökningsdag: 20 oktober 2026

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Göteborgs UniversitetAnsök senast 7 okt.

Researcher

Göteborg·Molekylärbiolog

The University of Gothenburg tackles society’s challenges with diverse knowledge. 58 000 students and 6800 employees make the university a large and inspiring place to work and study. Strong research and attractive study programmes attract researchers and students from around the world. With new knowledge and new perspectives, the University contributes to a better future. The Institute of Biomedicine is involved in both research and education. In both of these areas, we focus on fundamental knowledge of the living cell – what it consists of, how it works, how its function is directed by the genetic material, and how it interacts with various kinds of micro-organisms. Using this knowledge, we try to elucidate the causes of diseases, and find new ways to diagnose and treat them. The Institute is composed of the following four departments: The Department of Infectious Diseases The Department of Microbiology and Immunology The Department of Medical Biochemistry and Cell Biology The Department of Laboratory Medicine At present, the institute has about 315 employees and approximately 450 million SEK in total assets. The Sahlgrenska Academy, Department of Biomedical and Clinical Sciences, Division of Medical Chemistry and Cell Biology, Mitochondrial Genome Maintenance and Expression Group is recruiting a researcher for a temporary position. The group currently consists of approximately 15 researchers, including 4 PhD students and 2 principal investigators. Duties In this project, the candidate will investigate the biochemical and cell biological mechanisms that regulate mitochondrial DNA replication. The focus is on understanding how the involved proteins interact and how disease-causing mutations affect replication efficiency and genome stability. The work includes a combination of in vitro biochemical assays and cell-based methods. More information about the research group and our work is available at www.falkenberglab.org. Qualifications PhD in a relevant subject area. The applicant should have experience conducting research at an internationally competitive level in mitochondrial biology. Research experience will be assessed based on scientific publications. In-depth knowledge and extensive experience in mitochondrial DNA replication and gene expression is required, as well as documented expertise in protein chemistry and cell biology methods. The working language in the laboratory is English, and excellent proficiency in both spoken and written English is an absolute requirement. Employment The position is a temporary appointment 90% of full-time for 12 months, with placement at the Department of Biomedical and Clinical Sciences. Start date as agreed upon. Contact information for the post If you have questions about the position, you are welcome to contact Professor Maria Falkenberg. Phone: +46 (0)73 230 91 19. Email: maria.falkenberg@medkem.gu.se Unions Union representatives at the University of Gothenburg can be found here: https://www.gu.se/en/work-at-the-university-of-gothenburg/how-to-apply-for-a-position#collective-agreement-and-union-representatives Application To apply for a position at the University of Gothenburg, you have to create an account in our recruitment system. Submit your application via the University of Gothenburg’s recruitment portal by clicking the “Apply” button. It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline. The application should contain proof of completed PhD. Applications must be received by: 2026-10-07 The University works actively to achieve a working environment with equal conditions, and values the qualities that diversity brings to its operations. Salaries are set individually at the University. In accordance with the National Archives of Sweden’s regulations, the University must archive application documents for two years after the appointment is filled. If you request that your documents are returned, they will be returned to you once the two years have passed. Otherwise, they will be destroyed. In connection to this recruitment, we have already decided which recruitment channels we should use. We therefore decline further contact with vendors, recruitment and staffing companies.Öppen för alla Vi fokuserar på din kompetens, inte dina övriga förutsättningar. Vi är öppna för att anpassa rollen eller arbetsplatsen efter dina behov.

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Göteborgs UniversitetAnsök senast 25 okt.

Postdoctoral fellow in Structural studies of mitochondrial DNA replication

GÖTEBORG·Molekylärbiolog

This postdoctoral position is part of a research project funded by a Wallenberg Scholar grant. The postdoctoral researcher will work in an interdisciplinary team with expertise in molecular biology, biochemistry and structural biology. The project aims to understand the molecular mechanisms that govern mitochondrial DNA replication and gene expression, and how defects in these processes contribute to human disease. Subject area Structural studies of mitochondrial DNA replication Subject area description Mitochondrial DNA replication is essential for maintaining mtDNA integrity and stability and thereby for normal mitochondrial function and cellular energy production. Defects in the replication process can lead to mtDNA depletion or deletions and cause mitochondrial disease. Our research aims to understand the molecular mechanisms that govern replication of human mtDNA. We combine structural biology, in vitro biochemistry and cell biology to investigate how the mitochondrial DNA replication machinery is organized and regulated. A particular focus is on structural and functional studies of the protein complexes involved in mtDNA replication and on understanding how disease-associated mutations affect these processes. Job assignments In this project, In this project, the postdoctoral researcher will carry out structural and functional studies of protein and protein-DNA complexes involved in mitochondrial DNA replication. A central aim will be to determine structures of replication complexes using single-particle cryo-electron microscopy (cryo-EM) and use these structures to understand how the proteins interact and regulate mtDNA replication at the molecular level. The work will include preparation and biochemical characterization of protein complexes, cryo-EM sample preparation and grid optimization, as well as processing and structural analysis of cryo-EM data. Structural findings will be combined with in vitro biochemical analyses to test mechanistic models and investigate how disease-associated mutations affect the function of the replication machinery. The postdoctoral researcher is expected to drive the project independently while working closely with other members of the research group and our collaborators. Eligibility The eligibility criteria for employing teaching staff are set out in Chapter 4 of the Higher Education Ordinance and in the Appointment Procedure for Teaching Posts at the University of Gothenburg. To be eligible for appointment as a postdoc, the applicant is required to have a doctoral degree, a doctoral degree in art or a foreign degree that is deemed to be equivalent to a doctoral degree. This eligibility requirement must be met before the employment decision is made. In the first instance, those who have completed their degree no more than three years prior to the end of the application period shall be considered. Those who have completed their degree more than three years prior to the end of the application period may also be considered in the first instance if special grounds exist. Special grounds relate to leave of absence due to illness, parental leave, commissions of trust within union organisations, service within the defence services or other similar circumstances, as well as clinical service or service/assignment relevant to the subject area. Assessment criteria We are seeking a highly motivated researcher with a doctoral degree in structural biology, biochemistry, molecular biology or a related field. Documented experience in structural studies of proteins or macromolecular complexes using cryo-electron microscopy is required. Experience in protein purification and protein biochemistry is also required. Experience in single-particle cryo-EM, including sample preparation, grid optimization, data processing and structural analysis, is particularly meritorious. Experience in structural studies of protein-DNA complexes is a strong advantage. Knowledge of mitochondrial systems and experience in cloning, mutagenesis, protein expression, cell culture and in vitro biochemical analyses are considered merits. Great emphasis will be placed on scientific skills and the ability to independently plan, carry out and analyse research. The work involves close collaboration both within and outside the research group, making good teamwork and communication skills important. The candidate is expected to have strong scientific curiosity and the ability to work both independently and as part of an interdisciplinary team. Excellent spoken and written English is required, as the research group operates in an international environment. Regulations for the evaluation of qualifications for academic positions are given in Chapter 4, Section 3 - 4 of the Higher Education Ordinance. Employment The employment is full time and temporary, two years with the possibility of one year's extension, with placement at the Institute of Biomedicine. First day of employment as agreed. Contact information Please contact: Maria Falkenberg, Professor, e-mail: maria.falkenberg@medkem.gu.se. Unions Union representatives at the University of Gothenburg can be found here: https://www.gu.se/en/work-at-the-university-of-gothenburg/how-to-apply-for-a-position#collective-agreement-and-union-representatives Application Submit your application via the University of Gothenburg’s recruitment portal by clicking the “Apply” button. It is your responsibility to ensure that the application is complete as per the vacancy notice, and that the University receives it by the final application deadline. The application should contain: - A cover letter giving a brief description of previous research experience, and a motivation to why you are applying - A CV including a list of publications - Contact details of two references - Proof of completed PhD Applications must be received by: 2026-10-02. Information for International Applicants Choosing a career in a foreign country is a big step. Thus, to give you a general idea of what we and Gothenburg have to offer in terms of benefits and life in general for you and your family/spouse/partner please visit: https://www.gu.se/en/about-the-university/welcome-services https://www.movetogothenburg.com/

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